HSE Proposal to withdraw approval of the active substance mepanipyrim
28 Apr 2026
HSE has conducted a review of the approval of the active substance mepanipyrim and proposes to withdraw the approval. A current approval for this active is as a fungicide in strawberries, trade name Frupica SC, with an original expiry date of 31/10/31.
HSE reviewed the approval of mepanipyrim in light of new scientific information which indicated that the active substance may no longer satisfy the criteria for approval.
The review considered the potential endocrine disrupting properties in humans and wild mammals for the EAS (oestrogen, androgen and steroidogenesis) modalities.
The review concluded that mepanipyrim met the criteria to be classified as having endocrine disrupting properties in humans for the EAS modalities.
HSE therefore proposes to withdraw approval of mepanipyrim in GB.
Details of this proposal will now be forwarded to the World Trade Organisation for consultation with trading partners.
Further information and developments relating to the approval of mepanipyrim will be recorded in the GB approval register on the HSE website.